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The process will have increased safety. For example, the Chinese are already using human fetal liver stem cells in people. I'm not exaggerating when I say that using such cells to treat human disease has never been tried before, and the results so far have been unremarkable. But use of fetal liver stem cells is pretty much risk-free. That is a huge advantage.
There will be a lot of research. Because the technology is so new, there will be a lot of research trying to figure out its true uses and more. There will be a lot of trial and error. Especially with stem cells, the first cells to be transplanted to humans in any meaningful quantities will likely be embryos. That's going to be a bit of a setback for the pro-life lobby. Still, that's the way science works: trial and error.
Blood donation is the most effective source of stem cells by far, but it's also the most hit-and-miss. In fact, HLA typing, the gold standard of blood group matching, is not even close to perfect.
Given long-standing blood shortages in the west, it makes sense to look to the less controlled and more passionate potential donors - university students, for example - and look to stem cells. It's the perfect solution.
Given the rise of the East and China in particular, expect the first viable stem cell therapies, using whatever the breakthrough technologies are, in a few years. It's likely not to be a decade, and it's not likely it will be a cure for anything, but it will be a huge step forward in the repair and healing of the human body.
For one, stem cell therapies are at the very early stages of development. So while we are talking about a very long time from now, the technology is still in its infancy. Chinese scientists are not going to be dumbfounded by the technologies, and they will likely be more nimble and better at homing in on the tweaks and mistakes.
The researchers began their work with mouse stem cells but have now found that their results in the mice also work in humans, so that there is future hope for people with diseases that are not normally treatable by stem cell therapies. As usual, more research will be needed to fully demonstrate that it is safe and effective in humans.
It is not clear how long it will take to get to this stage, and whether it will take longer to be a true success than the generation of iPS cells, which is already well established. But there is a real opportunity to develop a new generation of therapeutics in which many patients may be helped.
This means that, in some ways, SENS is already a reality: we have technologies capable of slowing the aging process; we have technologies capable of repairing damage at the level of individual cells or even at the level of the whole animal; and we have a partial understanding of how the mechanisms of rejuvenation are triggered in mice. In a sense, this is what reality looks like for the first generation of SENS therapies. And what it will look like when we have therapies that can really make a difference to human lives. 827ec27edc